【研究简介】
从事细菌毒素以及宿主和病原菌相互作用研究。主要成果发表于 Cell、Science、Nature Chemical Biology、Nature communications、Cell& host等期刊上。先后获清华大学高精尖中心卓越学者、哈佛华人生命科学杰出研究奖等奖励，并受到Charles A. King Fellowship 经费资助。曾受邀到美国华人生物科学家学会国际研讨会（SCBA）、美国微生物协会年会（ASM）和欧洲分子生物学实验（EMBL）做报告。
实验室研究方向包括：
1. 鉴定全新毒素，研究细菌毒素功能和分子机制。
2. 研究宿主和病原菌相互作用。
3. 改造毒素和设计受毒素启发的工具
【荣誉奖励】
1. 国家重大人才项目入选者（青年）
2. 哈佛华人生命科学杰出研究奖
【代表性成果】
1. Tian, S., Xiong, X., Zeng, J., Wang, S., Tremblay, B., Chen, P., Chen, B., Liu, M., Chen, P., Sheng, K., Zeve,D., Qi, W., Breault, D., Rodríguez, C., Gerhard, R., Jin, R., Andrew C. Doxey, A., Dong, M. (2022). Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants. Nature Communications, 13(1), 1-19. PMID: 36351897
2. Xiong, X. *, Tian, S. *, Yang, P. *, Lebreton, F. *, Bao, H., Sheng, K., Yin, L., Chen, P., Zhang. J., Qi. W., Ruan, R., Wu, H., Chen, H., Breault, D., Wu, H., Earl, A., Gilmore, M., Abraham, J., Dong, M. (2022). Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell, 185(7), 1157-1171. PMCID: PMC8978092.
3. Blum, T., Liu, H., Packer, M., Xiong, X., Lee, P.-G., Zhang, S., Richter, M., Minasov, G., Satchell, K., Dong. M., Liu, R. D. (2021). Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science, 371(6531), 803-810. PMCID: PMC8175023.
4. Zhao, D., Li, Y., Xiong, X., Chen, Z., & Li, H. (2017). YEATS domain—A histone acylation reader in health and disease. Journal of Molecular Biology, 429(13), 1994-2002. Review. PMID: 28300602.
5. Xiong, X., Panchenko, T., Yang, S., Zhao, S., Yan, P., Zhang, W., Xie, W., Li, Y., Zhao, Y., Allis, D., Li, H. (2016). Selective recognition of histone crotonylation by double PHD fingers of MOZ and DPF2. Nature Chemical Biology, 12(12), 1111-1118. PMCID: PMC5253430.
6. Zhang, X., Zhao, D., Xiong, X., He, Z., Li. H. (2016). Multifaceted histone H3 methylation and phosphorylation readout by the plant homeodomain finger of human nuclear antigen Sp100C. Journal of Biological Chemistry, 291(24), 12786-12798. PMCID: PMC4933467.
7. Zhao, D., Zhang, X., Guan, H., Xiong, X., Shi, X., Deng, H., Li, H. (2016). The BAH domain of BAHD1 is a histone H3K27me3 reader. Protein & Cell, 7(3), 222-226. PMCID: PMC4791424.
8. Zhou, Q., Lin, H., Wang, S., Wang, S., Ran, Y., Liu, Y., Ye, W., Xiong, X., Zhong, B., Shu, H., Wang, Y. Y. (2014). The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. Cell Host & Microbe, 16(4), 450-461. PMID: 25299331.
