【研究简介】

本课题组从事针对重要呼吸道病原相关的疫苗研发，并以此为基础进行底层免疫机制探索，尤其聚焦于呼吸道黏膜免疫诱导和效应机制，探索黏膜免疫细胞动态调控共性规律，指导疫苗理性设计，开发黏膜靶向的新型病毒载体，以期获得更安全、更高效、更广谱、更持久的疫苗。

【荣誉奖励】

国家重大人才项目入选者（青年）

【代表性成果】

1. Yu J*, Collier AY*, Rowe M, Mardas F, Ventura JD, Wan H, Miller J, Powers O, Chung B, Siamatu M, Hachmann NP, Surve N, Nampanya F, Chandrashekar A, Barouch DH. 2022. Neutralization of the SARS-CoV-2 Omicron BA.1 and BA.2 Variants. N Engl J Med. 386:1579-1580.

2. J. Yu*, L. H. Tostanoski*, L. Peter*, N. B. Mercado*, K. McMahan*, S. H. Mahrokhian*, J. P. Nkolola*, J. Liu*, Z. Li, A. Chandrashekar, et al. 2020. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science. 369, 806-811.

3. J. Yu*, L. H. Tostanoski*, N. B. Mercado*, K. McMahan*, J. Liu*, C. Jacob-Dolan*, A. Chandrashekar*, C. Atyeo, D. R. Martinez, T. Anioke, E. A. Bondzie, A. Chang, S. Gardner, V. M. Giffin, D. L. Hope, F. Nampanya, J. Nkolola, S. Patel, O. Sanborn, D. Sellers, H. Wan, T. Hayes, K. Bauer, L. Pessaint, D. Valentin, Z. Flinchbaugh, R. Brown, A. Cook, D. Bueno-Wilkerson, E. Teow, H. Andersen, M. G. Lewis, A. J. Martinot, R. S. Baric, G. Alter, F. Wegmann, R. Zahn, H. Schuitemaker, D. H. Barouch. 2021. Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques. Nature. 596, 423-427.

4. G. Alter*, J. Yu*, J. Liu*, A. Chandrashekar*, E. N. Borducchi*, L. H. Tostanoski*, K. McMahan*, C. Jacob-Dolan*, D. R. Martinez, A. Chang, et al. 2021. Immunogenicity of Ad26. COV2. S vaccine against SARS-CoV-2 variants in humans. Nature. 596, 268-272.

5. K. McMahan*, J. Yu*, N. B. Mercado*, C. Loos*, L. H. Tostanoski*, A. Chandrashekar*, J. Liu*, L. Peter, C. Atyeo, A. Zhu, et al. 2021. Correlates of protection against SARS-CoV-2 in rhesus macaques. Nature. 590, 630-634.

6. Yu, J., Thomas, P.V., McMahan, K., Jacob-Dolan, C., Liu, J., He, X., Hope, D., Martinez, E.J., Chen, W.H., Sciacca, M., et al. 2022. Protection against SARS-CoV-2 Omicron BA.1 variant challenge in macaques by prime-boost vaccination with Ad26.COV2.S and SpFN. Sci Adv. 8, eade4433.

7. Chandrashekar A*, Yu J*, McMahan K*, Jacob-Dolan C*, Liu J*, He X*, Hope D, Anioke T, Barrett J, Chung B, Hachmann NP, Lifton M, Miller J, Powers O, Sciacca M, Sellers D, Siamatu M, Surve N, VanWyk H, Wan H, Wu C, Pessaint L, Valentin D, Van Ry A, Muench J, Boursiquot M, Cook A, Velasco J, Teow E, Boon ACM, Suthar MS, Jain N, Martinot AJ, Lewis MG, Andersen H, Barouch DH. 2022. Vaccine protection against the SARS-CoV-2 Omicron variant in macaques. Cell. 185:1549-1555 e11.

8. Yu J, Thomas PV, Sciacca M, et al. 2023. Ad26.COV2.S and SARS-CoV-2 spike protein ferritin nanoparticle vaccine protect against SARS-CoV-2 Omicron BA.5 challenge in macaques. Cell Rep Med. 4(4):101018.

9. Liu J*, Yu J*, McMahan K*, et al. 2022. CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques. Sci Immunol. 7(77):eabq7647.

10. Yu J*, Collins ND*, Mercado NB, et al. 2022. Protective Protective Efficacy of Gastrointestinal SARS-CoV-2 Delivery against Intranasal and Intratracheal SARS-CoV-2 Challenge in Rhesus Macaques. J Virol. 96(2):e0159921.