【研究简介】

主要专注于细胞增殖、衰老和命运变化研究，利用体外与体内活细胞成像和计算机辅助跟踪技术，获取细胞变化中时间和空间上的关键信息，通过在时空上精细可控的操作来探索呼吸系统组织中细胞谱系建成的因果关系。我们的长期目标是建立可定量的理论模型来实现细胞命运变化的解释与预测，为我们了解基本的生命活动过程-微观分子层面的信息如何导致宏观表型的变化提供理论框架，同时基于这些理论框架对呼吸疾病提出有效可行的干预手段。

【荣誉奖励】

1. 国家重大人才项目入选者（青年）

2. 广东省重大人才工程创新团队核心成员

3. 广州市优秀专家

4. 广州市黄埔区优秀人才（创新）

【代表性成果】

1. Mingwei Min, Yao Rong, Tian Chengzhe, and Sabrina L. Spencer. 2020. Temporal Integration of Mitogen History in Mother Cells Controls Proliferation of Daughter Cells. Science. 368(6496):1261–65.

2. Mingwei Min and Sabrina L. Spencer. 2019. Spontaneously Slow-Cycling Subpopulations of Human Cells Originate from Activation of Stress-Response Pathways. PLoS Biology. 17(3):e3000178.

3. Iain Miller, Mingwei Min, Chen Yang, Chengzhe Tian, Sara Gookin, Dylan Carter, and Sabrina L. Spencer. 2018. Ki67 Is a Graded Rather than a Binary Marker of Proliferation versus Quiescence. Cell Reports. 24(5):1105-1112 e5.

4. Sara Gookin, Mingwei Min, Harsha Phadke, Mingyu Chung, Justin Moser, Iain Miller, Dylan Carter, and Sabrina L. Spencer. 2017. A Map of Protein Dynamics during Cell-Cycle Progression and Cell-Cycle Exit. PLoS Biology. 15(9):e2003268.

5. Mingwei Min, Tycho E T Mevissen, Maria De Luca, David Komander, and Catherine Lindon. 2015. Efficient APC/C Substrate Degradation in Cells Undergoing Mitotic Exit Depends on K11 Ubiquitin Linkages. Molecular Biology of the Cell. 26(24):4325–32.

6. An Gong and Mingwei Min. 2022. Measuring the Size and Growth of Single Cells. Biophysics Reports. 8(3):150–57.