【研究简介】

英国格拉斯哥大学博士，长期从事新型核酸恒温扩增技术的开发和应用、基于表观遗传学的癌症早筛检测技术的开发和应用、以及核酸现场即时快速检测平台相关的研究。近年来在国际知名期刊发表TOP SCI 论文30余篇，包括Nature communication, PNAS, ACS NANO和 Angewandte等；申请发明专利23项，授权15项；所研发的产品获得过盖茨基金会的资助以及WHO的推荐。

【代表论文 Selected Publications】

1. Gaolian Xu#, Hao Yang#, Jiani Qiu#, Julien Reboud, LinQing Zhen, Wei Ren, Hong Xu, Jonathan M. Cooper, Hongchen Gu. Sequence terminus dependent PCR for site-specific mutation and modification. Nature communication.2023; 14: 1169.

2. Gaolian Xu, Julien Reboud, Yunfei Guo, Hao Yang, Hongchen Gu, Chunhai Fan, Xiaohua Qian, and Jonathan M. Cooper. Programmable Design of Isothermal Nucleic Acid Diagnostic Assays through Abstraction-based Models. Nature communications. 2022; 13,1635.

3. Hongbo Shan#, Yang Wang#, Tao Wu#, Binwu Ying*, Gaolian Xu*. Development of Asymmetric Hairpins-mediated Nucleic Acid Isothermal Amplification-based Lateral Flow Detection of Mycobacterium Tuberculosis. Sensors and Actuators B: Chemical, 2022; 350,130836.

4. Julien Reboud#, Gaolian Xu#, Alice Garrett, Moses Adriko, Zhugen Yang, Edridah M. Tukahebwa, Candia Rowell, Jonathan M. Cooper. Paper Microfluidic and Lateral flow detection Based-Multiplexed Malaria Diagnostics in a Remote Clinic in Uganda. Proceedings of the National Academy of Sciences of the United States of America, 2019;116(11):4834-4842.

5. Gaolian Xu, Hang Zhao, Julien Reboud, Jonathan M. Cooper. Cycling of Rational Hybridization Chain Reaction to Enable Enzyme-Free DNA-Based Clinical Diagnosis. ACS Nano. 2018;12(7):7213-7219.